On February 27, 2019, the three Torah scrolls, in the possession of Regensburg's Jewish Community, were ceremoniously carried over into the Torah shrine of the new synagogue. The new house of prayer is located, by and large, exactly where the old synagogue had been inaugurated in 1912 and burnt down in 1938.

In the autumn of 1945, the Jewish Community Regensburg (still bearing the English name; the German name "Jüdische Gemeinde Regensburg" followed in 1950) demanded the building of a new synagogue. But instead, as first steps the following happened: a Jewish high school came into being in 1946, a Kindergarten in 1951, an Orthodox cheder school in 1953, including a full-time rabbi. The old workdays' prayer room of the community building on Luzengasse served as the synagogue. In 1969, a so-called "multi-functional hall" (Mehrzwecksaal) was built right where the synagogue had stood when it was burnt down by the Nazis. In January 1971, this hall was also inaugurated as a synagogue. In 1986, a sheathing of rubble stone was put on the exterior wall facing the street to symbolize the broken history of the German Jews. Additionally, a large-sized, bronze-sheeted memorial tablet commemorates the story of the five deportations of Jews from Regensburg - as part of the genocide perpetrated by the Nazis -, which can be viewed again today.

In 2013, a group of mostly non-Jewish citizens, the "Förderverein Neue Regensburger Synagoge", formed an association with the intent of building a new synagogue. The group collected money for a competition of ten architects which took place in 2015. It was won by the Berlin-based architects' firm 'Büro Staab Architekten'. "Stone by stone we will give back the synagogue to the Jewish Community which was destroyed in the pogrom night of 1938", was the promise. The "Förderverein" managed to do just that; it secured grants for the construction costs of nine million Euros: from Germany's federal government, from the state of Bavaria, the city of Regensburg, the Jewish Community and from private sponsors. The cornerstone for this distinctive building was laid in October 2016; the synagogue was inaugurated on February 27, 2019.